What is the name of the genetic mutation that causes white blood cell malfunction leading to increased susceptibility to inflammatory diseases?

Wiskott-Aldrich Syndrome is the correct answer because it is a genetic disorder that impacts the immune system, specifically affecting the function of white blood cells. This syndrome is characterized by eczema, combined immune deficiency, and a tendency to develop bleeding due to low platelet counts. The malfunction of white blood cells in individuals with Wiskott-Aldrich Syndrome leads to an inability to effectively combat infections and increased susceptibility to inflammatory diseases.

Other choices represent different conditions that do not primarily center on white blood cell malfunction related to inflammatory diseases. Severe Combined Immunodeficiency (SCID) is another immune deficiency, but it does not specifically link to inflammatory diseases the way Wiskott-Aldrich Syndrome does. Down Syndrome is a genetic condition typically associated with developmental delays and does not primarily affect immune response in this manner. Cystic Fibrosis is a genetic disorder that primarily affects the respiratory and digestive systems rather than white blood cell function. Thus, the characteristics and implications of Wiskott-Aldrich Syndrome clearly align it as the chosen response.