Which of the following medications might cause ototoxic hearing loss?

Ototoxic hearing loss refers to hearing impairment resulting from the toxic effects of certain medications on the inner ear, particularly affecting the cochlea, which is crucial for hearing.

Cisplatin, a chemotherapy agent, is well-known for its potential to cause ototoxicity, especially in patients receiving high doses or those who have pre-existing hearing issues. This drug can damage hair cells within the cochlea, leading to hearing loss.

Aspirin and ibuprofen, both nonsteroidal anti-inflammatory drugs (NSAIDs), are also associated with ototoxicity, particularly when taken in high doses or for prolonged periods. Aspirin-induced ototoxicity can lead to a condition known as "salicylate ototoxicity," characterized by ringing in the ears (tinnitus) and hearing loss.

Given the information about these medications, the correct answer encompasses all the listed medications, as each one has a documented potential to cause ototoxic hearing loss, particularly under certain conditions or dosages. This comprehensive understanding of how various drugs can impact auditory function is important for medical coding professionals, as they need to accurately document and understand the implications of treatment plans.